Molecular biology and genetics of lung cancer 3
Angiogenesis in lung cancer 13
Contemporary issues in staging of lung cancer 31
Lung cancer surgery 47
Radiobiology of normal lung tissue and lung tumours 59
Radiation time, dose, and fractionation in the treatment of lung cancer 67
Treatment planning and conformal radiotherapy 77
Target volumes in non-small cell lung cancer 97
Target volumes in small cell lung cancer 111
Radioprotectors and chemoprotectors in the management of lung cancer 123
Lung cancer chemotherapy for radiation oncologists 135
Radiotherapy and chemotherapy - fundamentals and preclinical data 155
Radiotherapy in early stage non-small cell lung cancer 169
Postoperative radiotherapy for non-small cell lung carcinoma 189
Photodynamic therapy 199
Radiochemotherapy in locally advanced non-small cell lung cancer 207
Chemotherapy or chemoradiotherapy followed by surgical resection for non-small cell lung cancer 223
Palliative external beam thoracic radiotherapy 247
Intraoperative electron beam radiotherapy in lung cancer 255
Intraluminal radiotherapy 269
Limited disease of small-cell lung cancer 277
Prophylactic cranial irradiation in small-cell lung cancer 287
Radiation therapy for recurrent lung cancer 297
Radiotherapy of lung cancer in elderly patient 309
Advances in supportive and palliative care for lung cancer patients 321
Hematological toxicity in lung cancer 339
Radiation-induced lung and heart toxicity 351
Spinal cord 367
Radiation therapy-related toxicity : esophagus 373
Brain toxicity 383
Quality of life in radiation oncology of lung cancer 395
Prognostic factors in lung cancer 411
Intensity-modulated radiation therapy for lung cancer 423
Stereotactic radiotherapy and gated therapy 435
Novel substances in the treatment of lung cancer for radiation oncologists 447
PET scanning in staging and evaluation of response to treatment of lung cancer 461
Heavy particles in lung cancer 473
Translational research in radiation oncology of lung cancer 481
Pitfalls in the design, conduct and analysis of randomised clinical trials 495
New directions in the evaluation and presentation of clinical research in lung cancer 505
Although decades of laboratory and clinical research have led to incremental improvement in treatment outcome, lung cancer remains one of the most deadly diseases. This volume is unique in being devoted solely to the radiation oncology of lung cancer, and will be of great value to all who are involved in the diagnosis and treatment of the disease. Both non-small cell and small cell lung cancer are considered in detail. Current state-of-the-art treatment strategies and novel approaches that promise further improvements in outcome are explained and evaluated, with the aid of high-quality illustrations. Treatment-related toxicity is discussed, and further individual chapters focus on topics such as quality of life studies, prognostic factors and pitfalls in the design and analysis of clinical trials.
