Table of Contents
1 Introduction to cancer biology 1
2 Cancer epidemiology 4
3 Chemical and radiation carcinogenesis 25
4 Methods of molecular analysis 49
5 Genomic stability and DNA repair 77
6 Viruses and cancer 100
7 Oncogenes and tumor suppressor genes 123
8 Cellular signaling 142
9 Cell proliferation and tumor growth 167
10 Cell death 194
11 Tumor progression and metastasis : cellular, molecular, and microenvironmental factors 205
12 Angiogenesis 231
13 Imaging in oncology 249
14 Molecular and cellular basis of radiotherapy 261
15 The scientific basis of radiotherapy 289
16 Pharmacology of anticancer drugs 322
17 Cellular and molecular basis of drug treatment for cancer 349
18 Drug resistance 376
19 Hormones and cancer 400
20 Cancer and the immune system 431
21 Biological therapy of cancer 453
22 Guide to studies of diagnostic tests, prognostic factors, and treatments 485
Book Description
This concise text examines cancer causation and biology as well as the biology underlying cancer treatment. Thoroughly updated and reorganized with five new chapters, the Fourth Edition emphasizes new development in molecular biology, hormone therapy, and the pharmacology of anti-cancer drugs. Features updated coverage of the basic science of radiotherapy and experimental radiation in addition to expansive coverage of new drugs developments