Introduction.
- Advances in genetics: dominant forms.
- Advances in genetics: recessive forms.
- Genetically modified animal models.
- Genotype-phenotype correlations.
- ARVC/D in spontaneous animal models.
- Endomyocardial biopsy and autopsy features.
- Cell adhesion pathology.
- Ultrastructural substrates.
- Possible or contributing role of viruses.
- Diagnosis of ARVC/D: Task Force Criteria including modifications for family members.
- Strengths and weaknesses of the Task Force Criteria: proposed modifications.
- ARVC/D versus right ventricular outflow tract tachycardia.
- ECG and signal average ECG.
- Echocardiography.
- MR and CT imaging.- Angiocardiography.
- Electrophysiologic study including voltage mapping.
- Antiarrhythmic drug therapy and risk stratification.
- Catheter ablation.
- Implantable cardioverter defibrillator.
- Management of heart failure.
- Sudden death in athletes.
This book covers all aspects (biological, pathological, genetic, clinical and therapeutical) of arrhythmogenic right ventricular cardiomyopathy/dysplasia, a recent cardiomyopathy which represents a very high risk of sudden death in the young and in athletes. The monograph presents the results of 5-year research program on ARVC/D supported by grants of both the European Commission and the NIH, which enabled the discovery of seven disease-causing genes, thus opening new avenues for the early identification of affected patients and for sudden death prevention.
A panel of top scientists, both European and Americans, contributed to this volume, which will be an essential reference for professionals and residents in cardiology, radiology, human genetics, and sport medicine