Part 1: Key Concepts in Respiratory Genetics
~ Overview of human genetics ~ Phenotypes for Human Respiratory Genetics ~ Testing for association in genetic studies ~ Sample Collection and Genotyping for Human Respiratory Genetics ~ Molecular characterization of genetic variation: sample collection and processing in human respiratory genetics ~ Molecular characterization of genetic variation: genetic variation, genotyping, and sequencing ~ Bioinformatics: public databases and SNPs ~ Bioinformatics: genomics and proteomics in lung disease: microarrays and bioinformatics issues ~ Functional genomics: clinical functional genomics ~ Functional genomics: expression and purification of recombinant proteins ~ Functional genomics: functional characterization of a protein ~ Functional genomics: biophysical analysis of proteins and protein–protein interactions ~ Functional genomics: crystallography, nuclear magnetic resonance, and modeling ~ Functional genomics: functional analysis of mutant proteins in cells ~ Genomic physiology in animals ~ Pharmacogenetics
Part 2: Obstructive lung diseases
~ Asthma genetics ~ Chronic obstructive pulmonary disease ~ Cystic fibrosis
Part 3: Interstitial lung diseases
~ Idiopathic pulmonary fibrosis ~ Sarcoidosis
Part 4: Miscellaneous pulmonary conditions
~ Pulmonary hypertension ~ Genetics of lung cancer ~ Respiratory infections ~ Congenital, metabolic, and neuromuscular diseases ~ Other rare lung diseases: disorders of surfactant homeostasis ~ Other rare lung diseases: lymphangioleiomyomatosis ~ Other rare lung diseases: Hermansky–Pudlak Syndrome
There has been a recent explosion of knowledge in the field of respiratory genetics. This authoritative text brings together current knowledge in respiratory genetics in a single volume.
The book includes a comprehensive introductory section to provide guidance and aid understanding of key basic concepts in respiratory genetics, including statistical methods, sample collection, bioinformatics, and functional genomics. This is followed by a series of disease-specific chapters that review epidemiology, natural history, monogenic determinants, complex disease components, disease management, and likely future developments.
Respiratory Genetics is an essential reference for pulmonologists, translational researchers, and clinical geneticists, and the text will also be a useful library reference.
Annotated references to make extensive lists of references more useful to the reader and to encourage self-directed learning among both trainees and practicing physicians
Each chapter is summarized by a list of key learning points
In depth coverage of genetic influences on major respiratory diseases
State-of-the-art reviews of practical and theoretical issues in complex disease genetic research
Edited by a world-renowned team of editors, supported by internationally respected contributors
Highly illustrated, with several chapters in full color
