SECTION 1: PHYSIOLOGY AND PATHOPHYSIOLOGY
1 Maldigestion and Malabsorption
2 Microbial Interactions with Gut Epithelium
3 Inflammation
4 Motility
5 Liver Function and Dysfunction
5.1 Bile Formation and Cholestasis
5.2 Fibrogenesis and Cirrhosis
5.3 Normal Hepatocyte Function and Mechanisms of Dysfunction
6 Pancreatic Function and Dysfunction
7 Mitochondrial Function and Dysfunction
8 Gastrointestinal Injury
8.1 Drug-Induced Bowel Injury
8.2 Radiation Enteritis
SECTION 2: CLINICAL PRESENTATION OF DISEASE
9 Acute Diarrhea
10 Persistent Diarrhea
11 Protein-Losing Enteropathy
12 Vomiting
13 Colic and Gas
14 Abdominal Pain
15 Abdominal Masses
16 Gastrointestinal Bleeding
16.1 Upper
16.2 Lower
17 Growth Failure
18 The Gastrointestinal System in Malnutrition
19 Obesity
20 Munchausen Syndrome by Proxy: Factitious Disorder by Proxy
SECTION 3: CLINICAL MANIFESTATIONS AND MANAGEMENT
Mouth and Esophagus
21 Disorders of the Oral Cavity
22 Congenital Anomalies of the Mouth and Esophagus
23 Disorders of Deglutition
24 Gastroesophageal Reflux
25 Esophagitis
26 Other Motor Disorders
27 Injuries of the Esophagus
The Stomach and Duodenum
28 Congenital Anomalies of the Stomach and Duodenum
29 Gastritis
29.1 Helicobacter pylori and Peptic Ulcer Disease
29.2 Other Causes
30 Esophageal and Gastric Neoplasms
31 Motor Disorders including Pyloric Stenosis
The Intestine
32 Congenital Anomalies of the Intestine
33 Hernias
34 Peritonitis
35 Benign Perianal Lesions
36 The Surgical Abdomen
37 Appendicitis
38 Intestinal Infections
38.1 Bacterial Infections
38.2 Food and Waterborne Infections
38.3 Viral Infections of the Intestinal Tract
38.4 Parasitic and Fungal Infections
38.5 Bacterial Overgrowth
39 Gastrointestinal Manifestations of Immunodeficiency
39.1 Gastrointestinal Manifestations of Primary Immunodeficiency
Diseases
39.2 HIV and Other Secondary Immunodeficiencies
40 Intestinal Failure
40.1 Short-Bowel Syndrome and Intestinal Adaptation
40.2 Small Bowel Transplantation
40.3 Aspects of Surgery
40.4 Outcomes
41 Inflammatory Bowel Disease
41.1 Crohn Disease
41.2 Ulcerative Colitis
41.3 Undetermined Colitis and Other Inflammatory Diseases
41.4 Surgical Aspects of Inflammatory Bowel Disease in Children
42 Necrotizing Enterocolitis
43 Congenital Disease of Dysfunction and Absorption
43.1 Genetically Determined Dissaccharidase Deficiency
43.2 Congenital Intestinal Transport Defects
43.3 Congenital Enteropathy Involving Intestinal Mucosa Development
44 Enteropathy
44.1 Celiac Disease
44.2 Food Allergic Enteropathy
44.3 Autoimmune Enteropathy
45 Intestinal Tumors
45.1 Intestinal Polyps And Polyposis
45.2 Other Neoplasms
46 Hypomotility Disorders
46.1 Idiopathic Constipation
46.2 Dysmotilities
46.3 Hirschsprung Disease
46.4 Chronic Intestinal Pseudo-Obstruction Syndrome
47 Secretory Tumors Affectng the Gut
48 The Gastrointestinal System in Systemic Endocrinopathies
The Liver
49 Approach To Neonatal Cholestasis
50 Disorders of the Biliary Tract
50.1 Disorders of the Intrahepatic Ducts
50.2 Biliary Atresia
50.3 Disorders of the Biliary Tract
51 Postnatal Infections of the Liver
51.1a Viral Hepatitis B
51.1b Hepatitis C Virus
51.1c Other (A, D, EBV, CMV)
51.2 Bacterial, Parasitic, and Other Infections
51.3 Liver Infections in Aids and Other Immune Disorders
52 Autoimmune Liver Disease
53 Drug Induced Hepatotoxicity in Children
54 Liver Tumors
55 Genetic and Metabolic Disorders
55.1 Disorders of Carbohydrate Metabolism
55.2 Disorders of Amino Acid Metabolism
55.3 Inherited Abnormalities In Mitochondrial Fatty Acid Oxidation
55.4 Disorders of Bile Acid Synthesis and Metabolism
55.5 Disorders of Bilirubin Metabolism
55.6 Disorders of Biliary Transport
55.7 ¥á1-Antitrypsin Deficiency
55.8 Zellweger Syndrome and Other Disorders of Peroxisomal Metabolism
55.9 Lysosomal Acid Lipase Deficiencies: Wolman Disease and
Cholesteryl Ester Storage Disease
55.10 Wilson Disease
56 Parenteral Nutrition Associated Liver Disease
57 Systemic Conditions Affecting the Liver
58 Acute Liver Failure
59 Treatment of End-Stage Liver Disease
60 Liver Transplantation
61 Gallbladder Disease
The Pancreas
62 Congenital Anomalies of the Pancreas
63 Tumors of the Pancreas
64 Pancreatitis
64.1 Acute and Chronic
64.2 Juvenile Tropical Pancreatitis
65 Exocrine Pancreatic Dysfunction
65.1 Cystic Fibrosis
65.2 Shwachman Diamond Syndrome
65.3 Other Hereditary and Acquired Pancreatic Disorders
SECTION 4: DIAGNOSIS OF GASTROINTESTINAL DISEASES
66 Study Design
66.1 Outcomes Research on Diagnostic and Therapeutic Procedures in
Pediatric Gastroenterology
66.2 Methodology (Statistical Analysis, Test Interpretation, Basic
Principles of Screening with Application for Clinical Study)
66.3 Ethics/Regulatory Issues
67 Gastrointestinal Endoscopy
67.1 Patient Preparation and General Considerations
67.2 Upper Gastrointestinal Endoscopy
67.3 Ileo-colonoscopy and Enteroscopy
67.4 Gastrointestinal Endosonography
67.5 Endoscopic Retrograde Cholangiopancreatography in Children
68 Liver Biopsy Interpretation
69 Gastrointestinal Endoscopy: Intestinal Biopsy
70 Gastrointestinal Manometry Methodology And Indications
71 pH Measurements in Infants and Children
72 Pancreatic Function Tests
73 Breath Analysis
74 Imaging
74.1 Plain Radiographs And Contrast Studies In Pediatric
Gastroenterology
74.2 Cross-Sectional Imaging: Sonography, Computed Tomography,
Magnetic Resonance Imaging
74.3 Interventional Gastrointestinal Radiology
74.4 Radionuclide Diagnosis
SECTION 5: PRINCIPLES OF THERAPY
75 Nutritional Therapy
75.1 Fluid and Dietary Therapy of Diarrhea
75.2 Feeding Difficulties
75.3 Nutritional Assessment and Requirements
75.4 Nutrition Support
75.4a Parenteral
75.4b Enteral Nutrition
75.5 Special Dietary Therapy
75.6 Gastrointestinal Protective Nutrients and Factors
76 Drug Therapy
76.1 Immunosuppressive Therapies in Pediatric Gastroenterology
76.2 Modulation of Intestinal Flora
76.2a Antimicrobials
76.2b Probiotics-Specific Strains of the Healthy Human Gut Microbiota
with Preventive or Therapeutic Potential in Gastrointestinal Diseases
76.3 Motility
76.4 Pharmacological Therapy of Exocrine Pancreatic Insufficiency
76.5 Drug Therapy: Treatment of Acid-Peptic Disease
76.6 Alternative Medical Treatment
76.7 Adherence to Medical Regimens
77 Management of Surgical Patients
77.1 Complications after Gastrointestinal Surgery: A Medical
Perspective
77.2 The Pediatric Ostomy
77.3 Management of Surgical Patients: Psychological Aspects
This new edition of Pediatric Gastrointestinal Disease is dedicated
to the maintenance of a comprehensive approach to the practice of
Pediatric Gastroenterology. Considered to be the definitive reference
work, this fourth edition has been extensively reviewed. As a result,
the size and content of various sections have been modified and new
chapters have been added. Specific sections deal with Physiology and
Pathophysiology, Clinical Presentation of Disease, Clinical
Manifestations and Management (discussing the Mouth and Esophagus,
The Stomach and Duodenum, The Intestine, and The Pancreas), Diagnosis
of Gastrointestinal Diseases, and Principles of Therapy. Each author,
selected because of their particular expertise in the field, has
provided an authoritative and comprehensive account of their topic.
This volume¡¯s need-to-know information is supported by a varied
selection of tables, illustrations, and photographs. The two volumes
come with a CD-ROM with the complete text and color versions of the
illustrations.
New to the Fourth Edition:
• Expanded general principles and pathophysiology sections
• More chapters on perinatal spectrum of gastrointestinal disease in
children
• New therapeutic sections on comprehensive management
• Expanded endoscopy section