1 Phenomenology of depression : towards a neuroscientific perspective 1
2 Neurobiology of depression and new opportunities for treatment 51
3 Brain structural changes associated with depression 85
4 Functional imaging in secondary depressions 105
5 Co-morbidity of neurological and affective disorders : the model of the genetically epilepsy-prone rat 121
6 Depression in stroke : cause and consequence of brain dysfunction 159
7 Depression and epilepsy 173
8 Atypical presentations of depression in epilepsy : are they the expression of seizure-related brain dysfunction? 189
9 Depression in Parkinson¢¥s disease 199
10 Depression in Alzheimer¢¥s disease 239
11 Depression and multiple sclerosis 263
12 Traumatic brain injury and depression 275
This volume is a scholarly reference to published research results on the neurobiology and neuroanatomy of depression and the association of depression with disorders of the central nervous system. The book reviews and discusses aspects of recent research on the underlying mechanisms of depression, including neurotransmitter dysregulation, hypothalamus-pituitary-adrenal axis abnormalities, and cellular resistance. Illustrated with tables, graphs, and charts, Depression and Brain Dysfunction is the first book to include the recent advances in functional neuroimaging of the structural and anatomical defects in patients with significant symptoms of depression