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Table of Contents
Contributors
Preface
Unit 1 General Principles of Toxicology 1
1 History and Scope of Toxicology 3
2 Principles of Toxicology 6
3 Mechanisms of Toxicity 21
4 Risk Assessment 46
Unit 2 Disposition of Toxicants 57
5 Absorption, Distribution, and Excretion of Toxicants 59
6 Biotransformation of Xenobiotics 71
7 Toxicokinetics 98
Unit 3 Nonorgan-Directed Toxicity 109
8 Chemical Carcinogenesis 111
9 Genetic Toxicology 131
10 Developmental Toxicology 146
Unit 4 Target Organ Toxicity 161
11 Toxic Responses of the Blood 163
12 Toxic Responses of the Immune System 176
13 Toxic Responses of the Liver 194
14 Toxic Responses of the Kidney 208
15 Toxic Responses of the Respiratory System 220
16 Toxic Responses of the Nervous System 233
17 Toxic Responses of the Ocular and Visual System 252
18 Toxic Responses of the Heart and Vascular Systems 266
19 Toxic Responses of the Skin 288
20 Toxic Responses of the Reproductive System 301
21 Toxic Responses of the Endocrine System 316
Unit 5 Toxic Agents 331
22 Toxic Effects of Pesticides 333
23 Toxic Effects of Metals 348
24 Toxic Effects of Solvents and Vapors 360
25 Toxic Effects of Radiation and Radioactive Materials 372
26 Toxic Effects of Terrestrial Animal Venoms and Poisons 384
27 Toxic Effects of Plants 396
Unit 6 Environmental Toxicology 405
28 Air Pollution 407
29 Ecotoxicology
Unit 7 Applications of Toxicology 429
30 Food Toxicology 431
31 Analytic/Forensic Toxicology 440
32 Clinical Toxicology 447
33 Occupational Toxicology 453
34 Regulatory Toxicology 462
Self-Assessment Questions and Answers 468
Index 487