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Contents

Contributors

Preface

Part 1

Introduction to Clinical Medicine

1
The Practice of Medicine

The Editors

2
Global Issues in Medicine

Jim Yong Kim / Paul Farmer

3
Decision-Making in Clinical Medicine

Daniel B. Mark

4
Screening and Prevention of Diseases

Gary J. Martin

5
Principles of Clinical Pharmacology

Dan M. Roden

6
Women’s Health

Andrea Dunaif

7
Medical Disorders during Pregnancy

Robert L. Barbieri / John T. Repke

8
Medical Evaluation of the Surgical Patient

Wei C. Lau / Kim A. Eagle

9
Geriatric Medicine

Lisa B. Caruso / Rebecca A. Silliman

10
Complementary and Alternative Medicine

Stephen E. Straus

11
Palliative and End-of-Life Care

Ezekiel J. Emanuel / Joshua Hauser / Linda L. Emanuel

e1
The Safety and Quality of Health Care

David W. Bates

e2
Economic Considerations in the Practice of Medicine

David Meltzer

e3
Racial and Ethnic Disparities in Health Care
Joseph R. Betancourt / David Blumenthal

e4
Ethical Issues in Clinical Medicine

Bernard Lo

Part 2

Cardinal Manifestations and Presentation of Diseases

Section 1

Pain

12
Pain: Pathophysiology and Management

Howard L. Fields / Joseph B. Martin

13
Chest Discomfort

Thomas H. Lee

14
Abdominal Pain

William Silen

15
Headache

Peter J. Goadsby / Neil H. Raskin

16
Back and Neck Pain

John W. Engstrom

Section 2

Alterations in Body Temperature

17
Fever and Hyperthermia

Charles A. Dinarello / Reuven Porat

18
Fever and Rash

Elaine T. Kaye / Kenneth M. Kaye

e5
Atlas of Rashes Associated with Fever

Elaine T. Kaye / Kenneth M. Kaye

19
Fever of Unknown Origin

Jeffery A. Gelfand / Michael V. Callahan

20
Hypothermia and Frostbite

Daniel F. Danzl

Section 3

Nervous System Dysfunction

21
Syncope

Mark D. Carlson

22
Dizziness and Vertigo

Robert B. Daroff

23
Weakness and Paralysis

Michael J. Aminoff

24
Gait and Balance Disorders

Lewis Sudarsky

25
Numbness, Tingling, and Sensory Loss

Michael J. Aminoff / Arthur K.Asbury

26
Confusion and Delirium

S. Andrew Josephson / Bruce L. Miller

e6
Memory Loss

Thomas D. Bird / Bruce L. Miller

27
Aphasia, Memory Loss, and Other Focal Cerebral Disorders

M.-Marsel Mesulam

28
Sleep Disorders

Charles A. Czeisler / John W. Winkleman / Gary S. Richardson

Section 4

Disorders of Eyes, Ears, Nose, and Throat

29
Disorders of the Eye

Jonathan C. Horton

30
Disorders of Smell, Taste, and Hearing

Anil K. Lalwani

31
Pharyngitis, Sinusitis, Otitis, and Other Upper Respiratory Infections

Michael A. Rubin / Ralph Gonzales / Merle A. Sande

32
Oral Manifestations of Disease

Samuel C. Durso

e7
Atlas of Oral Manifestations of Disease

Samuel C. Durso / Janet A. Yellowitz

Section 5

Alterations in Circulatory and Respiratory Functions

33
Dyspnea and Pulmonary Edema

Richard M. Schwartzstein

34
Cough and Hemoptysis

Steven E. Weinberger / David A. Lipson

35
Hypoxia and Cyanosis

Eugene Braunwald

36
Edema

Eugene Braunwald / Joseph Loscalzo

e8
Approach to the Patient with a Heart Murmur

Patrick O’Gara / Eugene Braunwald

37
Palpitations

Joseph Loscalzo

Section 6

Alterations in Gastrointestinal Function

38
Dysphagia

Raj K. Goyal

39
Nausea, Vomiting, and Indigestion

William L. Hasler

40
Diarrhea and Constipation

Michael Camilleri / Joseph A. Murray

41
Weight Loss

Carol M. Reife

42
Gastrointestinal Bleeding

Loren Laine

43
Jaundice

Daniel S. Pratt / Marshall M. Kaplan

44
Abdominal Swelling and Ascites

Robert M. Glickman / Roshini Rajapaksa

Section 7

Alterations in Renal and Urinary Tract Function

45
Azotemia and Urinary Abnormalities
Bradley M. Denker / Barry M. Brenner

e9
Atlas of Urinary Sediments and Renal Biopsies

Agnes B. Fogo / Eric G. Neilsen

46
Fluid and Electrolyte Disturbances

Gary G. Singer / Barry M. Brenner

47
Hypercalcemia and Hypocalcemia
Sundeep Khosla

48
Acidosis and Alkalosis

Thomas B. DuBose, Jr.

Section 8

Alterations in Sexual Function and Reproduction

49
Sexual Dysfunction

Kevin T. McVary

50
Hirsutism and Virilization

David A. Ehrmann

51
Menstrual Disorders and Pelvic Pain

Janet E. Hall

Section 9
Alterations in the Skin

52
Approach to the Patient with a Skin Disorder

Thomas J. Lawley / Kim B. Yancey

53
Eczema, Psoriasis, Cutaneous Infections, Acne, and Other Common Skin Disorders

Calvin O. McCall / Thomas J. Lawley

54
Skin Manifestations of Internal Disease
Jean L. Bolognia / Irwin M. Braverman

55
Immunologically Mediated Skin Diseases

Kim B. Yancey / Thomas J. Lawley

56
Cutaneous Drug Reactions
Jean-Claude Roujeau / Robert S. Stern / Bruce C. Wintroub

57
Photosensitivity and Other Reactions to Light

David R. Bickers

e10
Atlas of Skin Manifestations of Internal Disease

Thomas J. Lawley / Stephen Templeton

Section 10

Hematologic Alterations

58
Anemia and Polycythemia

John W. Adamson / Dan L. Longo

59
Bleeding and Thrombosis

Barbara A. Konkle

60
Enlargement of Lymph Nodes and Spleen

Patrick H. Henry / Dan L. Longo

61
Disorders of Granulocytes and Monocytes

Steven M. Holland /John I. Gallin

e11
Atlas of Hematology and Analysis of Peripheral Blood Smears

Dan L. Longo

Part 3
Genetics and Disease

62
Principles of Human Genetics

J. Larry Jameson / Peter Kopp

63
Chromosome Disorders

Terry Hassold / Stuart Schwartz

64
The Practice of Genetics in Clinical Medicine

Susan Miesfeldt / J. Larry Jameson

65
Gene Therapy in Clinical Medicine
Katherine A. High

Part 4

Regenerative Medicine

66
Stem Cell Biology

Minoru S. H. Ko

67
Applications of Stem Cell Biology in Clinical Medicine

Jack A. Kessler

68
Hematopoietic Stem Cells

David T. Scadden / Dan L. Longo

69
Tissue Engineering

Jennifer Anderson /Joseph P. Vacanti

Part 5

Nutrition

70
Nutritional Requirements and Dietary Assessment

Johanna Dwyer

71
Vitamin and Trace Mineral Deficiency and Excess

Robert M. Russell / Paolo M. Suter

72
Malnutrition and Nutritional Assessment

Douglas C. Heimburger

73
Enteral and Parenteral Nutrition Therapy

Bruce R. Bistrian / David F. Driscoll

74
Biology of Obesity

Jeffrey S. Flier / Eleftheria Maratos-Flier

75
Evaluation and Management of Obesity

Robert F. Kushner

76
Eating Disorders

B. Timothy Walsh

Part 6

Oncology and Hematology

Section 1

Neoplastic Disorders

77
Approach to the Patient with Cancer

Dan L. Longo

78
Prevention and Early Detection of Cancer

Otis W. Brawley / Barnett S. Kramer

79
Cancer Genetics

Pat J. Morin / Jeffrey M. Trent / Francis S. Collins / Bert Vogelstein

80
Cancer Cell Biology and Angiogenesis

Robert G. Fenton / Dan L. Longo

81
Principles of Cancer Treatment

Edward A. Sausville / Dan L. Longo

82
Infections in Patients with Cancer

Robert Finberg

83
Cancer of the Skin

Arthur J. Sober / Hensin Tsao / Carl V. Washington

84
Head and Neck Cancer

Everett E. Vokes

85
Neoplasms of the Lung

John D. Minna / Joan H. Schiller

86
Breast Cancer

Marc E. Lippman

87
Gastrointestinal Tract Center

Robert J. Mayer

88
Tumors of the Liver and Biliary Tree

Brian I. Carr

89
Pancreatic Cancer

Yu Jo Chua / David Cunningham

90
Bladder and Renal Cell Carcinomas

Howard I. Scher / Robert J. Motzer

91
Benign and Malignant Diseases of the Prostate

Howard I. Scher

92
Testicular Cancer

Robert J. Motzer / George J. Bosl

93
Gynecologic Malignancies

Robert C. Young

94
Soft Tissue and Bone Sarcomas and Bone Metastases

Shreyaskumar R. Patel / Robert S. Benjamin

95
Carcinoma of Unknown Primary

Gauri R. Varadhachary /James L. Abbruzzese

96
Paraneoplastic Syndromes: Endocrinologic/Hematologic

J. Larry Jameson / Bruce E. Johnson

97
Paraneoplastic Neurologic Syndromes

Joseph Dalmau / Myrna R. Rosenfeld

e12
Thymoma

Dan L. Longo

e13
Late Consequences of Cancer and Its Treatment

Michael C. Perry / Dan L. Longo

Section 2

Hematopoietic Disorders

98
Iron Deficiency and Other Hypoproliferative Anemias

John W. Adamson

99
Disorders of Hemoglobin

Edward J. Benz

100
Megaloblastic Anemia

A. Victor Hoffbrand

101
Hemolytic Anemias and Anemias due to Acute Blood Loss

Lucio Luzzatto

102
Aplastic Anemia, Myelodysplasia, and Related Bone Marrow Failure Syndromes

Neal S. Young

103
Polycythemia Vera and Other Myeloproliferative Diseases

Jerry L. Spivak

104
Acute and Chronic Myeloid Leukemia

Meir Wetzler /John C. Byrd / Clara D. Bloomfield

105
Malignancies of Lymphoid Cells

Dan L. Longo

106
Plasma Cell Disorders

Nikhil C. Munshi / Dan L. Longo / Kenneth C. Anderson

107
Transfusion Biology and Therapy

Jeffery S. Dzieczkowski / Kenneth C. Anderson

108
Hematopoietic Cell Transplantation

Frederick R. Applebaum

Section 3

Disorders of Hemostasis

109
Disorders of Platelets and Vessel Wall

Barbara A. Konkle

110
Coagulation Disorders

Valder Arruda / Katherine High

111
Thrombosis Venous

F.R. Rosendaal / H.R. Büller

112
Antiplatelet, Anticoagulant, and Fibrinolytic Drugs

Jeffery L. Weitz

Part 7

Infectious Diseases

Section 1

Basic Considerations in Infectious Diseases

113
Introduction to Infectious Diseases: Host-Pathogen Interactions

Lawrence C. Madoff / Dennis L. Kasper

114
Molecular Mechanisms of Microbial Pathogenesis

Gerald B. Pier

115
Approach to the Acutely Ill Infected Febrile Patient

Tamar F. Barlam / Dennis L. Kasper

116
Immunization Principles and Vaccine Use

Gerald T. Keusch / Kenneth J. Bart / Mark Miller

117
Health Advice for International Travel

J.S. Keystone / P.E. Kozarsky

e14
Laboratory Diagnosis of Infectious Diseases

Alexander J. McAdam / Andrew B. Onderdonk

Section 2

Clinical Syndromes: Community-Acquired Infections

118
Infective Endocarditis

Adolf W. Karchmer

119
Infections of the Skin, Muscle, and Soft Tissues

Dennis L. Stevens

120
Osteomyelitis

Jeffrey Parsonnet

121
Intraabdominal Infections and Abscesses

Miriam J. Baron / Dennis L. Kasper

122
Acute Infectious Diarrheal Diseases and Bacterial Food Poisoning

Joan R. Butterton / Stephen B. Calderwood

123
Clostridium difficile-Associated Disease, Including Pseudomembranous Colitis

Dale N. Gerding / Stuart Johnson

124
Sexually Transmitted Infections: Overview and Clinical Approach

King K. Holmes

e15
Infectious Complications of Bites and Burns

Lawrence C. Madoff / Florencia Pereyra

Section 3

Clinical Syndromes: Nosocomial Infections

125
Health Care-Associated Infections

Robert A. Weinstein

126
Infections in Transplant Recipients

Robert Finberg /Joyce Fingeroth

Section 4

Approach to Therapy for Bacterial Diseases

127
Treatment and Prophylaxis of Bacterial Infections

Gordon L. Archer / Ronald E. Polk

Section 5

Diseases Caused by Gram-Positive Bacteria

128
Pneumococcal Infections

Daniel M. Musher

129
Staphylococcal Infections

Franklin D. Lowy

130
Strepococcal and Enterococcal Infections

Michael R. Wessels

131
Diphtheria and Other Infections Caused by Corynebacteria and Related Species

William R. Bishai / Jack R. Murphy

132
Infections Caused by Listeria monocytogenes

Elizabeth L. Hohmann / Daniel A. Portnoy

133
Tetanus

Elias Abrutyn

134
Botulism

Elias Abrutyn

135
Gas Gangrene and Other Clostridial Infections

Dennis L. Kasper /Lawrence C. Madoff

Section 6

Diseases Caused by Gram-Negative Bacteria

136
Meningococcal Infections

Lee M. Wetzler

137
Gonococcal Infections

Sanjay Ram / Peter A. Rice

138
Moraxella Infections

Daniel M. Musher

139
Haemophilus Infections

Timothy F. Murphy

140
Infections Due to the HACEK Group and Miscellaneous Gram-Negative Bacteria

Tamar F. Barlam / Dennis L. Kasper

141
Legionella Infection

Miguel Sabria / Victor L. Yu

142
Pertussis and Other Bordetella Infections

Scott A. Halperin

143
Diseases Caused by Gram-Negative Enteric Bacilli

Thomas A. Russo / James R. Johnson

144
Helicobacter Pylori Infections

John C. Atherton / Martin J. Blaser

145
Infections Due to Pseudomonas Species and Related Organisms

Reuben Ramphal

146
Salmonellosis

David A. Pegues / Samuel I. Miller

147
Shingellosis

Philippe Sansonetti / Jean Bergounioux

148
Infections Due to Campylobacter and Related Species

Martin J. Blaser

149
Cholera and Other Vibrioses

Matthew K. Waldor / Gerald T. Keusch

150
Brucellosis

Michael J. Corbel / Nicholas J. Beeching

151
Tularemia

Richard F. Jacobs / Gordon E. Schutze

152
Plague and Other Yersnia Infections

David T. Dennis / Grant L. Campbell

153
Bartonella Infections, Including Cat-Scratch Disease

David H. Spach / Emily Darby

154
Donovanosis

Gavin Hart

Section 7

Miscellaneous Bacterial Infections

155
Nocardiosis

Gregory A. Filice

156
Actinomycosis

Thomas A. Russo

157
Infections Due to Mixed Anaerobic Organisms

Dennis L. Kasper / Ronit Cohen-Poradosu

Section 8

Mycobacterial Diseases

158
Tuberculosis

Mario C. Raviglione / Richard J. O’Brien

159
Leprosy (Hansen’s Disease)

Robert H. Gelber

160
Nontuberculous Mycobacteria

C. Fordham von Reyn

161
Antimycobacterial Agents

Richard J. Wallace / David E. Griffith

Section 9
Spirochetal Disease

162
Syphilis

Sheila A. Lukehart

163
Endemic Treponematoses

Sheila A. Lukehart

164
Leptospirosis

Peter Speelman / Rudy Harkskeerl

165
Relapsing Fever

David T. Dennis

166
Lyme Borreliosis

Allen C. Steere

Section 10
Diseases Caused by Rickettsia, Mycoplasma, and Chlamydia

167
Rickettsial Diseases

David H. Walker / J. Stephen Dumler / Thomas Marrie

168
Infections Due to Mycoplasmas

William M. McCormack

169
Chlamydial Infections

Walter E. Stamm

Section 11

Viral Diseases: General Considerations

170
Medical Virology

Fred Wang /Elliott Kieff

171
Antiviral Chemotherapy, Excluding Antiretroviral Drugs

Lindsey R. Baden / Raphael Dolin

Section 12

Infections Due to DNA Viruses

172
Herpes Simplex Viruses

Lawrence Corey

73
Varicella-Zoster Virus Infections

Richard J. Whitley

174
Epstein-Barr Virus Infections, Including Infectious Mononucleosis

Jeffery I. Cohen

175
Cytomegalovirus and Human Herpesvirus Types 6, 7, and 8

Martin S. Hirsch

176
Molluscum Contagiosum, Monkeypox and Other Poxviruses Excluding Smallpox Virus

Fred Wang

177
Parvovirus Infections

Kevin E. Brown

178
Human Papillomavirus Infections

Richard C. Reichman

Section 13

Infections Due to DNA and RNA Respiratory Viruses

179
Common Viral Respiratory Infections and Severe Acute Respiratory Syndrome (SARS)

Raphael Dolin

180
Influenza

Raphael Dolin

Section 14

Infections Due to Human Immunodeficiency Virus and Other Human Retroviruses

181
The Human Retroviruses

Dan L. Longo /Anthony S. Fauci

182
Human Immunodeficiency Virus Disease: AIDS and Related Disorders

Anthony S. Fauci / H. Clifford Lane

Section 15

Infections Due to RNA Viruses

183
Viral Gastroenteritis

Umesh D. Parashar / Roger I. Glass

184
Enterovirus and Reoviruses Infections

Jeffery I. Cohen

185
Measles (Rubeola)

Anne Gershon

186
Rubella (German Measles)

Anne Gershon

187
Mumps

Anne Gershon

188
Rabies and Other Rhabdovirus Infections

Alan C. Jackson / Eric C. Johannsen

189
Infections Caused by Arthropod and Rodent-Borne Viruses

Clarence J. Peters

190
Ebola and Marburg Viruses

Clarence J. Peters

Section 16

Fungal and Algal Infections

191
Diagnosis and Treatment of Fungal Infections

John E. Edwards

192
Histoplasmosis

Chadi A. Hage / L. Joseph Wheat

193
Coccidioidomycosis

Neil M. Ampel

194
Blastomycosis

Stanley W. Chapman

195
Cryptococcosis

Arturo Casadevall

196
Candidiasois

John E. Edwards

197
Aspergillosis

David W. Denning

198
Mucormycosis

Alan M. Sugar

199
Miscellaneous Mycoses and Algal Infections

Stanley W. Chapman / Donna C. Sullivan

200
Pneumocystis Infection

A. Geroge Smulian /Peter D. Walzer

Section 17

Protozoal and Helminthic Infections: General Considerations

e16
Laboratory Diagnosis of Parasitic Infections

Sharon L. Reed / Charles E. Davis

201
Agents Used to Treat Parasitic Infections

Thomas A. Moore

e17
Pharmacology of Agents Used to Treat Parasitic Infections

Thomas A. Moore

Section 18

Protozoal Infections

202
Ambiasis and Infection with Free-Living Amebas

Sharon L. Reed

203
Malaria

Nicholas J. White / Joel G. Breman

204
Babesiosis

Jeffery Gelfand

e18
Atlas of Blood Smears of Malaria and Babesiosis

Nicholas J. White / Joel G. Breman

205
Leishmaniasis

Barbara L. Herwaldt

206
Trypanosomiasis

Louis V. Kirchhoff

207
Toxoplasma Infections

Lloyd H. Kasper

208
Protozoal Intestinal Infections and Trichomoniasis

Peter F. Weller

Section 19

Helminthic Infections

209
Trichinella and Other Tissue Nematodes

Peter F. Weller

210
Intestinal Nematodes

Peter F. Weller /Thomas B. Nutman

211
Filarial and Related Infections

Peter F. Weller / Thomas B. Nutman

212
Schistosomiasis and Other Trematode Infections

Adel A.F. Mahmoud

213
Cestodes

A. Clinton White, Jr. / Peter F. Weller

Part 8

Bioterrorism and Clinical Medicine

214
Microbioterrorism

H. Clifford Lane / Anthony S. Fauci

215
Chemical Bioterrorism

Charles G. Hurst / Jonathan Newmark / James A. Romano

216
Radiation Bioterrorism

Zelig A. Tochner / Eli Glatstein

Part 9

Disorders of Cardiovascular System

Section 1

Introduction to Cardiovascular Disorders

217
Basic Biology of the Cardiovascular System

Joseph Loscalzo / Peter Libby / Eugene Braunwald

218
Epidemiology of Cardiovascular Disease

Thomas A. Gaziano / J. Michael Gaziano

219
Approach to the Patient with Possible Cardiovascular Disease

Eugene Braunwald

Section 2

Diagnosis of Cardiovascular Disorders

220
Physical Examination of the Cardiovascular System

Robert A. O’Rourke /Eugene Braunwald

221
Electrocardiography

Ary L. Goldberger

e19
Atlas of Electrocardiography

Ary L. Goldberger

222
Noninvasive Cardiac Imaging: Echocardiography, Nuclear Cardiology, and MRI/CT Imaging

Rick Nishimura / Raymond J. Gibbons / James F. Glockner /A. Jamil Tajik

e20
Atlas of Noninvasive Cardiac Imaging

Rick Nishimura

223
Diagnostic Cardiac Catheterization and Angiography

Donald S. Baim

Section 3

Disorders of Rhythm

224
Principles of Electrophysiology

Gordon F. Tomaselli

225
The Bradyarrhythmias

Gordon F. Tomaselli

226
The Tachyarrhythmias

Francis Marchlinksi

e21
Atlas of Cardiac Arrhythmias

Ary L. Goldberger

Section 4

Disorders of the Heart

227
Heart Failure and Cor Pulmonale

Douglas L. Mann

228
Cardiac Transplantation and Prolonged Assisted Circulation

Sharon A. Hunt

229
Congenital Heart Disease in the Adult

John S. Child

230
Valvular Heart Disease

Patrick O’Gara / Eugene Braunwald

231
Cardiomyopathy and Myocarditis

Joshua Wynne / Eugene Braunwald

232
Pericardial Disease

Eugene Braunwald

233
Tumors and Trauma of the Heart

Eric H. Awtry / Wilson S. Colucci

234
Cardiac Manifestations of Systemic Disease

Eric H. Awtry / Wilson S. Colucci

Section 5

Vascular Disease

235
The Pathogenesis, Prevention, and Treatment of Atherosclerosis

Peter Libby

e22
Atlas of Atherosclerosis

Peter Libby

236
The Metabolic Syndrome

Robert H. Eckel

237
Ischemic Heart Disease

Elliott M. Antman / Andrew P. Selwyn/ Eugene Braunwald / Joseph Loscalzo

238
Unstable Angina and Non-ST-Elevation Myocardial Infarction

Christopher P. Cannon / Eugene Braunwald

239
ST-Segment Elevation Myocardial Infarction

Elliott M. Antman / Eugene Braunwald

240
Percutaneous Coronary Intervention

Donald S. Baim

e23
Atlas of Percutaneous Revascularization

Donald S. Baim

241
Hypertensive Vascular Disease

Ted A. Kotchen

242
Diseases of the Aorta

Mark A. Creager / Joseph Loscalzo

243
Vascular Diseases of the Extremities

Mark A. Creager / Joseph Loscalzo

244
Pulmonary Hypertension

Stuart Rich

Part 10

Disorders of the Respiratory System

Section 1

Diagnosis of Respiratory Disorders

245
Approach to the Patient with Disease of the Respiratory System

David A. Lipson / Steven E. Weinberger

246
Disturbances of Respiratory Function

Steven E. Weinberger /Ilene M. Rosen

247
Diagnostic Procedures in Respiratory Diseases

Scott Manaker / Steven E. Weinberger

e24
Atlas of Chest Imaging

Patricia Kritek / John J. Reilly, Jr.

Section 2

Diseases of the Respiratory System

248
Asthma

Peter J. Barnes

249
Hypersensitivity Pneumonitis and Pulmonary Infiltrates with Eosinophilia

Joel N. Kline / Gary W. Hunninghake

250
Environmental Lung Disease

Frank E. Speizer / John R. Balmes

251
Pneumonia

Lionel A. Mandell / Richard Wunderink

252
Bronchiectasis and Lung Abscess

Gregory Tino / Steven E. Weinberger

253
Cystic Fibrosis

Richard C. Boucher

254
Chronic Obstructive Pulmonary Disease

John J. Reilly, Jr. / Edwin K. Silverman / Steven D. Shapiro

255
Interstitial Lung Diseases

Talmadge E. King, Jr.

256
Deep Venous Thrombosis and Pulmonary Thromboembolism

Samuel Z. Goldhaber

257
Disorders of the Pleura and Mediastinum

Richard W. Light

258
Disorders of Ventilation

Eliot A. Phillipson

259
Sleep Apnea

Neil J. Douglas

260
Lung Transplantation

Elbert P. Trulock

Part 11

Critical Care Medicine

Section 1

Respiratory Critical Care

261
Principles of Critical Care Medicine

John P. Kress / Jesse B. Hall

262
Acute Respiratory Distress Syndrome

Bruce D. Levy / Steve D. Shapiro

263
Mechanical Ventilatory Support

Edward P. Ingenito

Section 2

Shock and Cardiac Arrest

264
Approach to the Patient with Shock

Ronald V. Maier

265
Severe Sepsis and Septic Shock

Robert S. Munford

266
Cardiogenic Shock and Pulmonary Edema

Judith S. Hochman / David H. Ingbar

267
Cardiovascular Collapse, Cardiac Arrest, and Sudden Cardiac Death

Robert J. Myerberg / Agustin Castellanos

Section 3

Neurologic Critical Care

268
Coma

Allan H. Ropper

269
Neurologic Critical Care, Including Hypoxic-Ischemic Encephalopathy and Subarachnoid Hemorrhage

J. Claude Hemphill / Wade S. Smith

Section 4

Oncologic Emergencies

270
Oncologic Emergencies

Rasim Gucalp / Janice Dutcher

Part 12

Disorders of the Kidney and Urinary Tract

271
Cellular and Molecular Biology of the Kidney

Alfred L. George / Eric G. Neilson

272
Adaptation of the Kidney to Renal Injury

Raymond C. Harris / Eric G. Neilson

273
Acute Renal Failure

Kathleen D. Liu / Glenn M. Chertow

274
Chronic Kidney Disease

Joanne M. Bargman / Karl Skorecki

275
Dialysis in the Treatment of Renal Failure

Kathleen D. Liu / Glenn M. Chertow

276
Transplantation in the Treatment of Renal Failure

Charles B. Carpenter / Edgar L. Milford / Mohamed H. Sayegh

277
Glomerular Diseases

Julia B. Lewis / Eric G. Neilson

278
Polycystic Kidney Disease and Other Inherited Tubular Disorders

David J. Salant / Parul S. Patel

279
Tubulointerstitial Diseases of the Kidney

Alan S. L. Yu / Barry M. Brenner

280
Vascular Injury to the Kidney

Kamal F. Badr / Barry M. Brenner

281
Nephrolithiasis

John R. Asplin / Fredric L. Coe / Murray J. Favus

282
Urinary Tract Infections, Pyelonephritis, and Prostatitis

Walter E. Stamm

283
Urinary Tract Obstruction

Julian L. Seifter / Barry M. Brenner

Part 13

Disorders of the Gastrointestinal System

Section 1

Disorders of the Alimentary Tract

284
Approach to the Patient with Gastrointestinal Disease

William L. Hasler / Chung Owyang

285
Gastrointestinal Endoscopy

Louis Michel Wong Kee Song / Mark Topazian

e25
Video Atlas of Gastrointestinal Endoscopy

Mark Topazian

286
Diseases of the Esophagus

Raj. K. Goyal

287
Peptic Ulcer Disease and Related Disorders

John Del Valle

288
Disorders of Absorption

Henry J. Binder

289
Inflammatory Bowel Disease

Sonia Friedman / Richard S. Blumberg

290
Irritable Bowel Syndrome

Chung Owyang

291
Diverticular Disease and Common Anorectal Disorders

Susan L. Gearhart

292
Mesenteric Vascular Insufficiency

Susan L. Gearhart

293
Acute Intestinal Obstruction

Susan L. Gearhart / William Silen

294
Acute Appendicitis and Peritonitis

Susan L. Gearhart / William Silen

Section 2

Liver and Biliary Tract Disease

295
Approach to the Patient with Liver Disease

Marc Ghany /Jay H. Hoofnagle

296
Evaluation of Liver Function

Daniel S. Pratt / Marshall M. Kaplan

297
The Hyperbilirubinemias

Allan W. Wolkoff

298
Acute Viral Hepatitis

Jules L. Dienstag

299
Toxic and Drug-Induced Hepatitis

Jules L. Dienstag

300
Chronic Hepatitis

Jules L. Dienstag

301
Alcoholic Liver Disease

Mark E. Malliard / Michael F. Sorrell

302
Cirrhosis and Its Complications

Bruce R. Bacon

e26
Atlas of Liver Biopsies

Jules L. Dienstag / Atul K. Bhau

303
Genetic, Metabolic, and Infiltrative Diseases Affecting the Liver

Bruce R. Bacon

304
Liver Transplantation

Jules L. Dienstag /Raymond T. Chung

305
Diseases of the Gallbladder and Bile Ducts

Norton J. Greenberger / Gustav Paumgartner

Section 3

Disorders of the Pancreas

306
Approach to the Patient with Pancreatic Disease

Phillip P. Toskes / Norton J. Greenberger

307
Acute and Chronic Pancreatitis

Norton J. Greenberger / Phillip P. Toskes

Part 14

Disorders of the Immune System, Connective Tissue, and Joints

Section 1

The Immune System in Health and Disease

308
Introduction to the Immune System

Barton F. Haynes / Kelly A. Soderberg / Anthony S. Fauci

309
The Major Histocompatability Complex

Gerald T. Nepom

310
Primary Immune Deficiency Diseases

Max D. Cooper / Harry W. Schroeder, Jr.

e27
Primary Immunodeficiencies Associated with or Secondary to Other Diseases

Max D. Cooper

Section 2

Disorders of Immune-Mediated Injury

311
Allergies, Anaphylaxis, and Systemic Mastocytosis

K. Frank Austen

312
Autoimmunity and Autoimmune Diseases

Peter E. Lipsky / Betty Diamond

313
Systemic Lupus Erythematosus

Bevra Hannahs Hahn

314
Rheumatoid Arthritis

Peter E. Lipsky

315
Acute Rheumatoid Fever

Jonathan R. Carapetis

316
Systemic Sclerosis (Scleroderma) and Related Disorders

John Varga

317
Sjögren’s Syndrome

Haralampos M. Moutsopoulos

318
The Spondyloarthritides

Joel D. Taurog

319
The Vasculitis Syndromes

Carol A. Langford / Anthony S. Fauci

e28
Atlas of Clinical Imaging of the Vasculitic Diseases

Carol A. Langford / Anthony S. Fauci

320
Behçet’s Syndrome

Haralampos M. Moutsopoulos

321
Relapsing Polychondritis

Carol A. Langford /Bruce C. Gilliland

322
Sarcoidosis

Robert P. Baughman /Elyse E. Lower

323
Familial Mediterranean Fever and Other Hereditary Recurrent Fevers

Daniel L. Kastner

324
Amyloidosis

David C. Seldin / Martha Skinner

Section 3

Disorders of the Joints and Adjacent Tissues

325
Approach to Articular and Musculoskeletal Disorders

John J. Cush / Peter E. Lipsky

326
Osteoarthritis

David T. Felson

327
Gout and Other Crystal Arthropathies

H. Ralph Schumacher / Lan X. Chen

328
Infectious Arthritis

Lawrence C. Madoff

329
Fibromyalgia

Carol A. Langford /Bruce C. Gilliland

330
Arthritis Associated with Systemic Disease and Other Arthritides

Carol A. Langford / Bruce C. Gilliland

331
Periarticular Disorders of the Extremities

Carol A. Langford / Bruce C. Gilliland

Part 15

Endocrinology and Metabolism

Section 1

Endocrinology

332
Principles of Endocrinology

J. Larry Jameson

333
Disorders of the Anterior Pituitary and Hypothalamus

Shlomo Melmed / J. Larry Jameson

334
Disorders of the Neurohypophysis

Gary L. Robertson

335
Disorders of the Thyroid Gland

J. Larry Jameson / Anthony P. Weetman

336
Disorders of the Adrenal Cortex

Gordon H. Williams / Robert G. Dluhy

337
Pheochromocytoma

Hartmut P.H. Neumann

338
Diabetes Mellitus

Alvin C. Powers

339
Hypoglycemia

Phillip E. Cryer

340
Disorders of the Testes and the Male Reproductive System

Shalender Bhasin / J. Larry Jameson

341
Disorders of the Ovary and Female Reproductive Tract

Janet E. Hall

342
The Menopause Transition and Postmenopausal Hormone Therapy

JoAnn E. Manson /Shari S. Bassuk

343
Disorders of Sex Development

John C. Achermann / J. Larry Jameson

344
Endocrine Tumors of the Gastrointestinal Tract and Pancreas

Robert T. Jensen

345
Disorders Affecting Multiple Endocrine Neoplasia Syndromes

Camillo Jimenez / Robert Gagel

Section 2

Disorders of Bone and Mineral Metabolism

346
Bone and Mineral Metabolism in Health and Disease

F. Richard Bringhurst / Marie B. Demay / Stephen M. Krane / Henry M. Kronenberg

347
Diseases of the Parathyroid Gland and Other Hyper- and Hypocalcemia Disorders

John T. Potts, Jr.

348
Osteoporosis

Robert Lindsay / Felicia Cosman

349
Paget Disease and Other Dysplasias of Bone

Murray J. Favus /Tamara J. Vokes

Section 3

Disorders of Intermediary Metabolism

350
Disorders of Lipoprotein Metabolism

Daniel J. Rader / Helen H. Hobbs

351
Hemochromatosis

Lawrie W. Powell

352
The Porphyrias

Robert J. Desnik / Kenneth H. Astrin

353
Disorders of Purine and Pyrimidine Metabolism

Robert L. Wortmann

354
Wilson Disease

George J. Brewer

355
Lysosomal Storage Disease
Robert J. Hopkin / Gregory A. Grabowski

356
Glycogen Storage Diseases and Other Inherited Disorders of Carbohydrate Metabolism

Yuan-Tsong Chen

357
Heritable Disorders of Connective Tissue

Darwin J. Prockop / Malwina Czarny-Ratajczak

358
Inherited Disoders of Amino Acid Metabolism in Adults

Nicola Longo

359
Inherited Defects of Membrane Transport

Nicola Longo

e29
Atlas of Clinical Manifestations of Metabolic Diseases

J. Larry Jameson

Part 16

Neurologic Disorders

Section 1

Diagnosis of Neurologic Disorders

360
Mechanisms of Neurologic Disorders

Stephen Hauser / M. Flint Beal

361
Approach to the Patient with Neurologic Disease

Daniel H. Lowenstein / Joseph B. Martin / Stephen L. Hauser

362
Neuroimaging in Neurologic Disorders

William P. Dillon

e30
Atlas of Neuroimaging

Andre Furtado / William P. Dillon

e31
Electrodiagnostic Studies of Nervous System Disorders: EEG and EMG

Michael J. Aminoff

e32
Technique of Lumbar Puncture

Elizabeth Robbins / Stephen L. Hauser

Section 2

Diseases of the Central Nervous System

363
Seizures and Epilepsy

Daniel H. Lowenstein

364
Cerebrovascular Diseases

Wade S. Smith / Joey English / S. Claiborne Johnston

365
Dementia

Thomas D. Bird / Bruce L. Miller

366
Parkinson’s Disease and Other Extrapyramidal Disorders

Mahlon R. DeLong / Jorge L. Juncos

367
Hyperkinetic Movement Disorders

C. Warren Olanow

368
Ataxic Disorders

Roger N. Rosenberg

369
Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases

Robert H. Brown, Jr.

370
Disorders of the Autonomic Nervous System

Phillip A. Low / John W. Engstrom

371
Trigeminal Neuralgia, Bell’s Palsy, and Other Cranial Nerve Disorders

M. Flint Beal / Stephen L. Hauser

372
Diseases of the Spinal Cord

Stephen L. Hauser / Allan H. Ropper

373
Concussion and Other Head Injuries

Allan H. Ropper

374
Primary and Metastatic Tumors of the Nervous System

Stephen M. Sagar / Mark A. Israel

375
Multiple Sclerosis and Other Demyelinating Diseases

Stephen L. Hauser / Douglas S. Goodin

376
Meningitis, Encephalitis, Brain Abscess,and Empyema

Karen L. Roos / Kenneth L. Tyler

377
Chronic and Recurrent Meningitis

Walter J. Koroshetz / Morton N. Swartz

378
Prion Diseases

Stanley B. Prusiner / Bruce L. Miller

Section 3

Nerve and Muscle Disorders

379
Peripheral Neuropathy

Vinay Chaudhry

380
Guillain-Barre Syndrome and Other Immune-Mediated Neuropathies

Steven L. Hauser / Arthur K. Asbury

381
Mysathenia Gravis and Other Diseases of the Neuromuscular Junction

Daniel B. Drachman

382
An Approach to Muscular Dystrophy and Other Muscle Diseases

Robert H. Brown, Jr. / Anthony A. Amato / Jerry R. Mendell

383
Polymyositis, Dermatomyositis, and Inclusion Body Myositis

Marinos C. Dalakas

e33
Special Issues in Inpatient Neurologic Consultation

S. Andrew Josephson / Martin A. Samuels

Section 4

Chronic Fatigue Syndrome

384
Chronic Fatigue Syndrome

Stephen E. Straus

Section 5

Psychiatric Disorders

385
Biology of Psychiatric Disorders

Steve Hyman / Eric Kandel

386
Mental Disoders

Victor I. Reus

Section 6

Alcoholism and Drug Dependency

387
Alcohol and Alcoholism

Marc A. Schuckit

388
Opioid Drug Abuse and Dependence

Mark A. Schuckit

389
Cocaine and Other Commonly Abused Drugs

Jack H. Medelson / Nancy K. Mello

390
Nicotine Addiction

David M. Burns

Part 17

Poisoning, Drug Overdose, and Envenomation

e34
Heavy Metal Poisoning

Howard Hu

e35
Poisoning and Drug Overdosage

Christopher H. Linden / Michael J. Burns / Mark B. Mycyk

391
Disorders Caused by Reptile Bites and Marine Animal Exposures

Paul Auerbach / Robert Norris

e36
Ectoparasite Infestations and Arthropod Bites and Stings

Richard J. Pollack / James H. Maguire

International e Chapters

e37
Pulmonary Biomarkers in COPD

Peter J. Barnes

e38
Chagas’ Disease: Recent Advances in Diagnosis and Management

Andrei C. Sposito / Jose A.F. Ramires

Summaries of Chapters e1 to e36

Appendix

Laboratory Values of Clinical Importance

Alexander Kratz / Michael A. Pesce / Daniel J. Fink

Index