Table of Contents
1 Fish Oil and Importance of Its Ingredients in Human Diet 1
2 Transport, Synthesis, and Incorporation of n-3 and n-6 Fatty Acids in Brain Glycerophospholipids 47
3 Release of n-3 and n-6 Fatty Acids from Glycerophospholipids in Brain 79
4 Oxidation of Arachidonic and Docosahexaenoic Acids and Neurochemical Effects of Their Metabolites on Brain 105
5 Roles of Docosahexaenoic and Eicosapentaenoic Acids in Brain 151
6 Status of Docosahexaenoic Acid Levels in Aging and Consequences of Docosahexaenoic Acid Deficiency in Normal Brain 189
7 Status and Potential Therapeutic Importance of n-3 Fatty Acids in Neurodegenerative Disease 217
8 Status and Potential Therapeutic Importance of n-3 Fatty Acids in Acute Metabolic Trauma and Neurotraumatic Disorders 261
9 Status and Potential Therapeutic Importance of n-3 Fatty Acids in Neuropsychiatric Disorders 293
10 Status and Potential Therapeutic Importance of n-3 Fatty Acids in Other Neural and Non-neural Diseases 333
11 Perspective and Directions for Future Development on the Effects of Fish Oil Constituents on Brain 367
Index 385
It is becoming increasingly evident that the deficiency of n-3 fatty acids in diet is not only associated with cardiovascular diseases, but also involved in stroke, epilepsy and other neurological and neurodegenerative diseases, such as Alzheimer disease, Parkinson disease, and peroxisomal diseases. In his newest book, Beneficial Effects of Fish Oil on Human Brain, Dr. Akhlaq A. Farooqui expands on the status and therapeutic importance of n-3 fatty acids (major components of fish oil) and their mediators in normal brain and those with neurodegenerative and neuropsychiatric diseases. Farooqui presents the benefits of n-3 fatty acids on Western diet, which is enriched in n-6 fatty acids (major components of vegetable oil) and may promote the above neurological disorders. The book will present readers with cutting edge and comprehensive information on metabolism and roles of neural membrane n-3 fatty acids.
Neuroscientists, clinicians, neurologists, neuropathologists, opthamologists, dietitians, and nutritionists will find this book useful for understanding the molecular basis of n-3 fatty acids and their lipid mediators (resolvins and neuroprotectins) in neuroprotection in acute neural trauma (stroke, spinal cord trauma and head injury) and neurodegenerative diseases.