The pivotal role of mitochondrial functions in carcinogenesis is quite well established. However, the critical role of mitochondrial genome alterations to cancer development is muted in traditional textbooks. Recent scientific efforts have provided unequivocal evidence for mitochondrial genome mutations and content changes in cancer development, progression, and therapy. This pioneering book is a unique compilation of mitochondrial genome alterations in cancer.
While primarily focused on the emerging role of mitochondrial genome changes, bioenergetics and signaling pathways, attention is also given to the metabolic transformations of the cancer cell, as well as the established altered cell death processes that underlie cancer evolution and treatment resistance.
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Biography
Gabriel D. Dakubo is a founding member, and currently the Chief Medical Officer of Genesis Genomics Inc. (GGI), a pioneer biotechnology company in Thunder Bay, Ontario, Canada. The primary research focus of GGI is on the discovery, development and commercial application of mitochondrial DNA-based biomarkers for early cancer detection and monitoring